Tatyana Chtanova

Associate Professor

Associate Professor Tatyana Chtanova is the head of the Innate and Tumour Immunology laboratory, School of Biotechnology and Biomolecular Sciences, UNSW Sydney.  After undergraduate studies at the University of New South Wales, Tatyana was awarded her PhD in 2005 for her thesis work on specific gene expression signatures for novel T cell subsets, performed at the Garvan Institute.

Following her PhD, Tatyana was awarded the Human Frontier Science Program Fellowship to train at the University of California, Berkeley. During her fellowship she gained expertise in intravital microscopy and applied it to uncover a unique immunological response to inflammation called neutrophil swarming and a novel mechanism of immune evasion by pathogens.

Tatyana’s main research interest is in developing unique approaches such as two-photon microscopy and in situ photoconversion to understand fundamental immunological processes including infection, wound repair and cancer. The overall goal of Tatyana’s research program is to harness inflammation to develop new immunotherapy for cancer and promote wound healing.

Journal articles
add
Jakovija A; Chtanova T, 2023, 'Skin immunity in wound healing and cancer', Frontiers in Immunology, 14, http://dx.doi.org/10.3389/fimmu.2023.1060258
2023
Rogers NM; Zammit N; Nguyen-Ngo D; Souilmi Y; Minhas N; Meijles DN; Self E; Walters SN; Warren J; Cultrone D; El-Rashid M; Li J; Chtanova T; O'Connell PJ; Grey ST, 2023, 'The impact of the cytoplasmic ubiquitin ligase TNFAIP3 gene variation on transcription factor NF-κB activation in acute kidney injury', Kidney International, 103, pp. 1105 - 1119, http://dx.doi.org/10.1016/j.kint.2023.02.030
2023
Rojas-Canales D; Walters SN; Penko D; Cultrone D; Bailey J; Chtanova T; Nitschke J; Johnston J; Kireta S; Loudovaris T; Kay TW; Kuchel TR; Hawthorne W; O'Connell PJ; Korbutt G; Greenwood JE; Grey ST; Drogemuller CJ; Coates PT, 2023, 'Intracutaneous Transplantation of Islets within a Biodegradable Temporizing Matrix (BTM) as an Alternative Site for Islet Transplantation.', Diabetes, http://dx.doi.org/10.2337/db21-0841
2023
Yam AO; Bailey J; Lin F; Jakovija A; Youlten SE; Counoupas C; Gunzer M; Bald T; Woodruff TM; Triccas JA; Goldstein LD; Gallego-Ortega D; Grey ST; Chtanova T, 2023, 'Neutrophil Conversion to a Tumor-Killing Phenotype Underpins Effective Microbial Therapy', Cancer research, 83, pp. 1315 - 1328, http://dx.doi.org/10.1158/0008-5472.CAN-21-4025
2023
Moriya T; Hashimoto M; Matsushita H; Masuyama S; Yoshida R; Okada R; Furusawa A; Fujimura D; Wakiyama H; Kato T; Choyke PL; Kusumoto Y; Chtanova T; Kobayashi H; Tomura M, 2022, 'Near-infrared photoimmunotherapy induced tumor cell death enhances tumor dendritic cell migration', Cancer Immunology, Immunotherapy, 71, pp. 3099 - 3106, http://dx.doi.org/10.1007/s00262-022-03216-2
2022
Bartonicek N; Rouet R; Warren J; Loetsch C; Rodriguez GS; Walters S; Lin F; Zahra D; Blackburn J; Hammond JM; Reis ALM; Deveson IW; Zammit N; Zeraati M; Grey S; Christ D; Mattick JS; Chtanova T; Brink R; Dinger ME; Weatheritt RJ; Sprent J; King C, 2022, 'The retroelement Lx9 puts a brake on the immune response to virus infection', Nature, 608, pp. 757 - 765, http://dx.doi.org/10.1038/s41586-022-05054-9
2022
Ikebuchi R; Moriya T; Ueda M; Yasuda I; Kusumoto Y; Chtanova T; Tomura M, 2021, 'Cutting edge: Recruitment, retention, and migration underpin functional phenotypic heterogeneity of regulatory T cells in tumors', Journal of Immunology, 207, pp. 771 - 776, http://dx.doi.org/10.4049/jimmunol.2001083
2021
Moriya T; Kitagawa K; Hayakawa Y; Hemmi H; Kaisho T; Ueha S; Ikebuchi R; Yasuda I; Nakanishi Y; Honda T; Matsushima K; Kabashima K; Ueda M; Kusumoto Y; Chtanova T; Tomura M, 2021, 'Immunogenic tumor cell death promotes dendritic cell migration and inhibits tumor growth via enhanced T cell immunity', ISCIENCE, 24, http://dx.doi.org/10.1016/j.isci.2021.102424
2021
Jakovija A; Chtanova T, 2021, 'Neutrophil interactions with the lymphatic system', Cells, 10, http://dx.doi.org/10.3390/cells10082106
2021
Cultrone D; Zammit NW; Self E; Postert B; Han JZR; Bailey J; Warren J; Croucher DR; Kikuchi K; Bogdanovic O; Chtanova T; Hesselson D; Grey ST, 2020, 'A zebrafish functional genomics model to investigate the role of human A20 variants in vivo', Scientific Reports, 10, http://dx.doi.org/10.1038/s41598-020-75917-6
2020
Walters SN; Bailey JG; Rojas-Canales D; Drogemuller C; Loudovaris T; Kay TW; Korbutt G; Chtanova T; Greenwood JE; Coates TP; Grey ST, 2020, 'INNATE IMMUNE SENSING AND TISSUE REMODELING OF A BIODEGRADABLE TEMPERING MATRIX SUPPORTED ISLET GRAFT', Transplantation, 104, pp. S559 - S559, http://dx.doi.org/10.1097/01.tp.0000701564.71238.9c
2020
Yam A; Bailey J; Lin F; Jakovija A; Counoupas C; Triccas J; Gunzer M; Bald T; Grey S; Chtanova T, 2020, 'Microbial activation converts neutrophils into anti-tumor effectors', , http://dx.doi.org/10.1101/2020.08.21.259051
2020
Cultrone D; Zammit N; Self E; Postert B; Han JZR; Bailey J; Warren J; Croucher D; Kikuchi K; Bogdanovic O; Chtanova T; Hesselson D; Grey S, 2020, 'A zebrafish functional genomics model to investigate the role of human A20 variantsin vivo', , http://dx.doi.org/10.1101/2020.02.23.961763
2020
Yam AO; Chtanova T, 2020, 'Imaging the neutrophil: Intravital microscopy provides a dynamic view of neutrophil functions in host immunity', Cellular Immunology, 350, http://dx.doi.org/10.1016/j.cellimm.2019.01.003
2020
Hampton HR; Chtanova T, 2019, 'Lymphatic migration of immune cells', Frontiers in Immunology, 10, http://dx.doi.org/10.3389/fimmu.2019.01168
2019
Yam AO; Chtanova T, 2019, 'The ins and outs of chemokine-mediated immune cell trafficking in skin cancer', Frontiers in Immunology, 10, http://dx.doi.org/10.3389/fimmu.2019.00386
2019
Nakanishi Y; Ikebuchi R; Chtanova T; Kusumoto Y; Okuyama H; Moriya T; Honda T; Kabashima K; Watanabe T; Sakai Y; Tomura M, 2018, 'Regulatory T cells with superior immunosuppressive capacity emigrate from the inflamed colon to draining lymph nodes', Mucosal Immunology, 11, pp. 437 - 448, http://dx.doi.org/10.1038/mi.2017.64
2018
Torcellan T; Stolp J; Chtanova T, 2017, 'In vivo imaging sheds light on immune cell migration and function in cancer', Frontiers in Immunology, 8, pp. 309, http://dx.doi.org/10.3389/fimmu.2017.00309
2017
Torcellan T; Hampton HR; Bailey J; Tomura M; Brink R; Chtanova T, 2017, 'In vivo photolabeling of tumor-infiltrating cells reveals highly regulated egress of T-cell subsets from tumors', Proceedings of the National Academy of Sciences of the United States of America, 114, pp. 5677 - 5682, http://dx.doi.org/10.1073/pnas.1618446114
2017
Nobis M; Herrmann D; Warren SC; Kadir S; Leung W; Killen M; Magenau A; Stevenson D; Lucas MC; Reischmann N; Vennin C; Conway JRW; Boulghourjian A; Zaratzian A; Law AM; Gallego-Ortega D; Ormandy CJ; Walters SN; Grey ST; Bailey J; Chtanova T; Quinn JMW; Baldock PA; Croucher PI; Schwarz JP; Mrowinska A; Zhang L; Herzog H; Masedunskas A; Hardeman EC; Gunning PW; del Monte-Nieto G; Harvey RP; Samuel MS; Pajic M; McGhee EJ; Johnsson AKE; Sansom OJ; Welch HCE; Morton JP; Strathdee D; Anderson KI; Timpson P; del Monte Nieto G, 2017, 'A RhoA-FRET Biosensor Mouse for Intravital Imaging in Normal Tissue Homeostasis and Disease Contexts', Cell Reports, 21, pp. 274 - 288, http://dx.doi.org/10.1016/j.celrep.2017.09.022
2017
Read MN; Bailey J; Timmis J; Chtanova T, 2016, 'Leukocyte Motility Models Assessed through Simulation and Multi-objective Optimization-Based Model Selection', PLoS Computational Biology, 12, http://dx.doi.org/10.1371/journal.pcbi.1005082
2016
Hampton HR; Chtanova T, 2016, 'The lymph node neutrophil', Seminars in Immunology, 28, pp. 129 - 136, http://dx.doi.org/10.1016/j.smim.2016.03.008
2016
Hampton HR; Bailey J; Tomura M; Brink R; Chtanova T, 2015, 'Microbe-dependent lymphatic migration of neutrophils modulates lymphocyte proliferation in lymph nodes', Nature Communications, 6, http://dx.doi.org/10.1038/ncomms8139
2015
Gallego-Ortega D; Ledger A; Roden DL; Law AMK; Magenau A; Kikhtyak Z; Cho C; Allerdice SL; Lee HJ; Valdes-Mora F; Herrmann D; Salomon R; Young AIJ; Lee BY; Sergio CM; Kaplan W; Piggin C; Conway JRW; Rabinovich B; Millar EKA; Oakes SR; Chtanova T; Swarbrick A; Naylor MJ; O’Toole S; Green AR; Timpson P; Gee JMW; Ellis IO; Clark SJ; Ormandy CJ, 2015, 'ELF5 Drives Lung Metastasis in Luminal Breast Cancer through Recruitment of Gr1+ CD11b+ Myeloid-Derived Suppressor Cells', PLoS Biology, 13, http://dx.doi.org/10.1371/journal.pbio.1002330
2015
Suan D; Nguyen A; Moran I; Bourne K; Hermes JR; Arshi M; Hampton HR; Tomura M; Miwa Y; Kelleher AD; Kaplan W; Deenick EK; Tangye SG; Brink R; Chtanova T; Phan TG, 2015, 'T Follicular Helper Cells Have Distinct Modes of Migration and Molecular Signatures in Naive and Memory Immune Responses', Immunity, 42, pp. 704 - 718, http://dx.doi.org/10.1016/j.immuni.2015.03.002
2015
Chtanova T; Hampton HR; Waterhouse LA; Wood K; Tomura M; Miwa Y; Mackay CR; Brink R; Phan TG, 2014, 'Real-time interactive two-photon photoconversion of recirculating lymphocytes for discontinuous cell tracking in live adult mice', Journal of Biophotonics, 7, pp. 425 - 433, http://dx.doi.org/10.1002/jbio.201200175
2014
Suan D; Hampton HR; Tomura M; Kanagawa O; Chtanova T; Phan TG, 2013, 'Optimizing Fluorescence Excitation and Detection for Intravital Two-Photon Microscopy', Methods in Cell Biology, 113, pp. 311 - 323, http://dx.doi.org/10.1016/B978-0-12-407239-8.00014-8
2013
Tri P; Hampton H; Tomura M; Kanagawa O; Mackay C; Brink R; Chtanova T, 2011, 'Optical marking of migrating lymphocytes by two-photon photoconversion for single cell tracking and fate mapping', JOURNAL OF IMMUNOLOGY, 186, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000209751703169&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
2011
Phan TG; Chtanova T, 2010, 'Border patrol: SCS macrophages activate iNKT cells too', Immunology and Cell Biology, 88, pp. 619 - 621, http://dx.doi.org/10.1038/icb.2010.71
2010
Chtanova T; Han SJ; Schaeffer M; van Dooren GG; Herzmark P; Striepen B; Robey EA, 2009, 'Dynamics of T Cell, Antigen-Presenting Cell, and Pathogen Interactions during Recall Responses in the Lymph Node', Immunity, 31, pp. 342 - 355, http://dx.doi.org/10.1016/j.immuni.2009.06.023
2009
Schaeffer M; Han SJ; Chtanova T; Van Dooren GG; Herzmark P; Chen Y; Roysam B; Striepen B; Robey EA, 2009, 'Dynamic imaging of T cell-parasite interactions in the brains of mice chronically infected with Toxoplasma gondii', Journal of Immunology, 182, pp. 6379 - 6393, http://dx.doi.org/10.4049/jimmunol.0804307
2009
Chtanova T; Schaeffer M; Han SJ; van Dooren GG; Nollmann M; Herzmark P; Chan SW; Satija H; Camfield K; Aaron H; Striepen B; Robey EA, 2008, 'Dynamics of Neutrophil Migration in Lymph Nodes during Infection', Immunity, 29, pp. 487 - 496, http://dx.doi.org/10.1016/j.immuni.2008.07.012
2008
Chtanova T; Schaeffer M; Han SJ; van Dooren GG; Nollmann M; Herzmark P; Wei Chan S; Satija H; Camfield K; Aaron H; Striepen B; Robey EA, 2008, 'Dynamics of Neutrophil Migration in Lymph Nodes during Infection (DOI:10.1016/j.immuni.2008.07.012)', Immunity, vol. 29, pp. 661, http://dx.doi.org/10.1016/j.immuni.2008.09.007
2008
Ladi E; Schwickert TA; Chtanova T; Chen Y; Herzmark P; Yin X; Aaron H; Shiao WC; Lipp M; Roysam B; Robey EA, 2008, 'Thymocyte-dendritic cell interactions near sources of CCR7 ligands in the thymic cortex', Journal of Immunology, 181, pp. 7014 - 7023, http://dx.doi.org/10.4049/jimmunol.181.10.7014
2008
Yin X; Chtanova T; Ladi E; Robey EA, 2006, 'Thymocyte motility: Mutants, movies and migration patterns', Current Opinion in Immunology, 18, pp. 191 - 197, http://dx.doi.org/10.1016/j.coi.2006.02.004
2006
Liu SM; Xavier R; Good K; Newton R; Sisavanh M; Zimmer S; Deng C; Silva D; Frost M; Tangye SG; Rolph MS; Mackay C; Chtanova T, 2006, 'Immune cell transcriptome datasets reveal novel leukocyte subset-specific genes and genes associated with allergic processes', Journal of Allergy and Clinical Immunology, 118, pp. 496 - 503
2006
Ladi E; Yin X; Chtanova T; Robey EA, 2006, 'Thymic microenvironments for T cell differentiation and selection', Nature Immunology, 7, pp. 338 - 343, http://dx.doi.org/10.1038/ni1323
2006
Chtanova T; Newton R; Liu SM; Weininger L; Young TR; Silva DG; Bertoni F; Rinaldi A; Chappaz S; Sallusto F; Rolph MS; Mackay CR, 2005, 'Identification of T cell-restricted genes, and signatures for different T cell responses, using a comprehensive collection of microarray datasets', Journal of Immunology, 175, pp. 7837 - 7847, http://dx.doi.org/10.4049/jimmunol.175.12.7837
2005
Chtanova T; Tangye SG; Newton R; Frank N; Hodge M; Rolph MS; MacKay CR, 2004, 'T follicular helper cells express a distinctive transcriptional profile, reflecting their role as non-Th1/Th2 effector cells that provide help for B cells', Immunology, 173, pp. 68 - 78, http://www.sciencedirect.com/science/article/B6WVB-4CT743T-8S/2/9b15351f9890af8512188653155ef8a6
2004
Ng LG; Sutherland AP; Newton R; Qian F; Cachero T; Scott M; Thompson JS; Wheway JE; Groom JR; Sutton I; Xin C; Tangye SG; Kalled S; Mackay F; MacKay CR; Chtanova T, 2004, 'B cell-activating factor belonging to the TNF family (BAFF)-R is the principal BAFF receptor facilitating BAFF costimulation of circulating T and B cells', Immunology, 173, pp. 807 - 817, http://www.sciencedirect.com/science/article/B6WVB-4D3R5H1-BT/2/3c2f2e7efd269e3536db4fc4b03e365b
2004
Chtanova T; Mackay CR, 2001, 'T cell effector subsets: Extending the Th1/Th2 paradigm', Advances in Immunology, 78, pp. 233 - 266, http://dx.doi.org/10.1016/S0065-2776(01)78005-4
2001
Chtanova T; Kemp RA; Sutherland APR; Ronchese F; Mackay CR, 2001, 'Gene microarrays reveal extensive differential gene expression in both CD4+ and CD8+ type 1 and type 2 T cells', Journal of Immunology, 167, pp. 3057 - 3063, http://dx.doi.org/10.4049/jimmunol.167.6.3057
2001
Conference Abstracts
add
O'Reilly L; Suan D; Chtanova T; Biden TJ, 2016, 'Depletion of macrophages in mice fed a high-fat diet leads to a systemic inflammatory state and improved beta cell function', in DIABETOLOGIA, SPRINGER, GERMANY, Munich, Vol. 59, pp. S290 - S290, presented at 52nd Annual Meeting of the European-Association-for-the-Study-of-Diabetes (EASD), GERMANY, Munich, 12 September 2016 - 16 September 2016, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000398373701416&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
2016
Torcellan T; Hampton HR; Bailey J; Tomura M; Brink R; Chtanova T, 2016, 'Tumour-infiltrating T cells leave tumours to provide effector functions in draining lymph nodes', in EUROPEAN JOURNAL OF IMMUNOLOGY, WILEY-BLACKWELL, AUSTRALIA, Melbourne, Vol. 46, pp. 1006 - 1007, presented at International Congress of Immunology (ICI), AUSTRALIA, Melbourne, 21 August 2016 - 26 August 2016, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000383610402420&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
2016
Gallego-Ortega D; Ledger A; Roden D; Cho C; Allerdice SL; Lee HJ; Valdes-Mora F; Lee B; Kaplan W; Salomon R; Piggin C; Rabinovich B; Millar E; Chtanova T; Swarbrick A; Clark S; Ormandy C, 2015, 'The ETS transcription factor ELF5 drives metastasis via angiogenesis and recruitment of Gr-1+ CD11b+ myeloid derived suppressor cells in luminal breast cancer', in Clinical and Experimental Metastasis, Springer Verlag (Germany), Vol. 32, pp. 203 - 203, presented at MRS 15th International biennial congress of the metastasis research society, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000351601900067&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a
2015
Conference Papers
add
Read M; Timmis J; Chtanova T, 2015, 'Simulation-Based Analysis of in Situ Cellular Motility', in Proceedings of the 13th European Conference on Artificial Life, ECAL 2015, pp. 637, http://dx.doi.org/10.7551/978-0-262-33027-5-ch110
2015
Chtanova T; Hampton H; Welten S; Tomura M; Kanagawa O; Mackay CR; Phan T, 2011, 'DISSECTING THE ROLE OF NEUTROPHILS IN TUMOUR GROWTH AND METASTASIS WITH THE AID OF OPTICAL CELL TRACKING AND 2-PHOTON MICROSCOPY', in INFLAMMATION RESEARCH, BIRKHAUSER VERLAG AG, FRANCE, Paris, pp. 194 - 194, presented at 10th World Congress on Inflammation, FRANCE, Paris, 25 June 2011 - 29 June 2011, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000291358900531&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
2011

NHMRC Career Development Fellowship 1

Human Frontier Science Program Career Development award and Fellowship

Cancer Institute NSW Career Development award

  • CIA ARC Discovery Project grant
  • 2x CIA National Breast Cancer Foundation Investigator Initiated Research Scheme grant
  • 3x CIA NHRMC project grants
  • Avner Pancreatic Cancer Foundation grant
  • UNSW Futures Genomics Institute Grant Seed grant
  • Perpetual Impact Grant
Organisational units